Blar i forfatter "Kouyos, Roger D."

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    • Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level 

      Kachalov, Viacheslav N.; Nguyen, Huyen; Balakrishna, Suraj; Salazar-Vizcaya, Luisa; Sommerstein, Rami; Kuster, Stefan P.; Hauser, Anthony; Abel-Zur Wiesch Genannt Hülsho, Pia Karoline; Klein, E; Kouyos, Roger D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-29)
      Beta-lactam- and in particular carbapenem-resistant Enterobacteriaceae represent a major public health threat. Despite strong variation of resistance across geographical settings, there is limited understanding of the underlying drivers. To assess these drivers, we developed a transmission model of cephalosporin- and carbapenem-resistant <i>Klebsiella pneumoniae</i>. The model is parameterized using ...

    • Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota 

      Tepekule, Burcu; Abel zur Wiesch, Pia; Kouyos, Roger D.; Bonhoeffer, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-30)
      To understand how antibiotic use affects the risk of a resistant infection, we present a computational model of the population dynamics of gut microbiota including antibiotic resistance-conferring plasmids. We then describe how this model is parameterized based on published microbiota data. Finally, we investigate how treatment history affects the prevalence of resistance among opportunistic ...